Analysis of the T-cell autoimmunity against PLP, which showed that PLP is immunogenic for HLA-DRB1*1501- and HLA-DQB1*0602-Tg mice also revealed that the T-cell autoimmunity against PLP in both transgenics is predominantly directed against PLP139-151 and PLP175-194 epitopes, which are the immunodominant and encephalitogenic epitopes for SJL/J mice [43]. This evidence concerns the gene HLA-DRB1 and Autoimmunity.