In our studies, using the Caucasian MS-associated allelic genes (of the HLA-DR15 haplotype) we show the opposite scenario for the role of the HLA-DQ6 in anti-myelin autoimmunity in HLA-Tg mice, as the HLA-DQB1*0602 gene product determined susceptibility to PLP- as well as to MOBP-induced EAE. The gene discussed is HLA-DQB1; the disease is myeloid sarcoma.