HLA-DRB1 and Autoimmunity: It should be noted that the DRB1*1501-Tg line (originated from C. David and maintained in our animal facility as homozygotic line for several years) which is refractory to PLP139-151- and to PLP175-194-induced EAE, or to MOBP15-36- induced EAE [28], is susceptible in our hands to EAE induced by MOG35-55 and to MBP89-104 (data not shown), indicating that the disease-resistance or -susceptibility is the result of a selective DRB1*1501-associated Th2 autoimmunity, and DQB1*0602-associated Th1/Th17 autoimmunity, against PLP and MOBP in the setting of the these HLA-humanized mice.