Further investigation is required to understand how recognition of the same epitopes in the context of DQB1*0602 class-II molecule drives Th1/Th17 pathogenic T-cell autoimmunity, while the recognition of same epitopes in the context of DRB1*1501 class-II molecule drives more Th2 type autoimmunity. The gene discussed is HLA-DRB1; the disease is Autoimmunity.