Our results show that, unlike the previously reported HLA-DR-dependent susceptibility to MBP-, PLP-, or MOG-induced EAE, the pathogenic autoimmunity against PLP, as well as against MOBP [28], was dependent on HLA-DQB1*0602 rather than HLA-DRB1*1501. Here, HLA-DQB1 is linked to Autoimmunity.