Our recent studies in HLA-DR15-Tg mice showing that susceptibility to MOBP-induced EAE is determined by HLA-DQB1*0602, and not by DRB1*1501 [28], were the first to implicate DQB1*0602-associated autoimmunity in the pathogenesis of MS and to suggest DQ6 as an important disease predisposing, rather than just a disease-modifying allele, as previously suggested [30]. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.