These findings in the reductionist transgenic models are quite challenging since both DRB1*1501 and DQB1*0602 molecules are co-expressed in HLA-DR15+ MS patients, raising the question on whether the net T-cell autoimmunity against PLP, and particularly against the PLP139-151 and PLP175-194 epitopes, in HLA-DR15+ MS would be of Th1/Th17 pathogenic autoimmunity or more of anti-inflammatory Th2 type. This evidence concerns the gene HLA-DRB1 and Autoimmunity.