Similarly, the involvement of the (macro)autophagy pathway of protein turnover in AD has long been known [79–81, 91], and this has more recently been extended to non-AD tauopathies [77–79], where it now appears to play a largely disruptive role in autophagic protein turnover mechanisms that may well exacerbate tau toxicity in these diseases [80]. The gene discussed is MAPT; the disease is Alzheimer disease.