Moreover, since tau has been shown to modulate the activity of MT-associated motor proteins that mediate dendritic transport [64, 65], often in a disease-specific [66] or overexpression-induced [67] manner, it seems likely that toxicity resulting from tau accumulation at localized dendritic loci may have relevance to the pathogenesis of human tauopathies, which typically feature abnormal somatodendritic phosphotau accumulation. Here, MAPT is linked to tauopathy.