The spontaneously hypertensive rat (SHR) has at least seven expressed Sry loci whereas the normotensive Wistar Kyoto (WKY) rat has at least six [4], lacking Sry3. Sry transcripts have been observed in adult rat tissues consistent with blood pressure regulation [5], and one or more of the Sry loci play a role in the development of hypertension in SHR [6]. The gene discussed is SRY; the disease is hypertensive disorder.