Hormonal data analysis at the age of 24 years indicated a suboptimal testicular function (hypergonadotropic hypogonadism), FSH 12 and 17.5 U/L (normal 2.0–7.0 U/L), LH 5.6 and 8.4 U/L (normal 1.5–8.0 U/L), testosterone 13.2 and 16.2 (normal 10–30 nmol/L), Inhibin B 119 and 74 ng/L (normal 150–400 ng/L). This evidence concerns the gene PLOD1 and Hypergonadotropic hypogonadism.