Likewise, also the colon is characterized by high expression of BMP-2 [6, 8, 9], where genetic loss of signalling components is intimately associated with the development of both sporadic cancer [10, 11] and with genetic polyposis syndromes, in particular juvenile polyposis [12] and also in gastric and colorectal cancer methylation of the BMP-2 promoter is a frequent event [13]. The gene discussed is BMP2; the disease is juvenile polyposis syndrome.