EGFR and head and neck squamous cell carcinoma: Targeting EGFR using small molecule EGFR-tyrosine kinase inhibitors (TKI) such as gefitinib or monoclonal antibodies against EGFR (cetuximab) abrogates tumour growth in the preclinical HNSCC models (Erjala et al, 2006; Nozawa et al, 2006).