SPHK1 and cancer: Sphingosine kinase-1 (SphK1), the enzyme that generates S1P has oncogenic properties (Xia et al, 2000), contributes to cancer progression (Olivera et al, 1999), enhances tumour neovascularisation (Licht et al, 2003) and metastatic potential (Visentin et al, 2006) and is associated with a poor prognosis (Ruckhaberle et al, 2008).