The results of the prospective studies are rather inconsistent, however, with most studies showing no association of circulating IGF-I or IGFBP-3 levels with pancreatic cancer risk (Lin et al, 2004; Stolzenberg-Solomon et al, 2004; Wolpin et al, 2007; Douglas et al, 2010). The gene discussed is IGFBP3; the disease is familial pancreatic carcinoma.