MBNL1 and myotonic dystrophy type 1: Although C. elegans mbl-1 itself has not been shown to be a regulator of alternative splicing, it shares a significant amount of homology with human, mouse, and Drosophila MBNL sequences, binds to similar repetitive RNA sequences as human MBNL1, and co-localizes with CUG repeat-containing nuclear foci in a C. elegans model of DM1 [31,33].