HFE and hepatocellular carcinoma: In a modeling study using published life tables, age-specific cancer rates, and DNA studies of archived liver biopsy specimens, Haddow et al. [67] calculated the lifetime risk of HCC in a cohort of 5000 men with the common homozygous C282Y mutation in the HFE gene to be 23-fold compared with 1,000,000 normal men.