Growth factors as TFGβ, PDGF, BMPs, IGFs, FGFs, and l'u-PA (which stimulates TGFβ release) have been isolated in prostate cancer cells and stimulate osteoblastic differentiation and they have a role in growing and survival tumour cells itself [70, 74, 84, 85]. Here, TGFB1 is linked to neoplasm.