TGFB1 and neoplasm: Tumour cells produce IL-1-6-8-11, PgE2, TGFα, TGFβ, EGF, VEGF, TNF, CSF-1, GM-CSF, and M-CSF, which can directly or indirectly stimulate osteoclastic activity and then bone resorption [5, 12, 13, 72, 73].