PTHLH and breast cancer: About 70% of people who die from breast cancer will have radiological evidence of skeletal metastasis before their death and in 40% of cases the bone is the first metastatic site [11]; the estrogen receptors [11], the sialoprotein [15], the parathyroid-related peptide (PTHrP) [16], and 69 gene signature correlated with fibroblasts growth factors [17] are predictive markers of bone recurrence [12].