Subsequently, they and other groups further showed that expression of C4 as well as other intrabodies, namely, MW7, VL12.3, Happ1, and EM48, all of which bind to the polyQ adjacent regions in htt, leads to suppression of htt aggregation and neurodegeneration in cell culture, Drosophila, and mouse models of HD [60–67]. This evidence concerns the gene HTT and Huntington disease.