Depletion of CD8 cells prior to Ad5mTRAIL+CpG therapy resulted in a significant increase in primary renal tumor size (Ad5mTRAIL+CpG vs Ad5mTRAIL+CpG – CD8, p = .002), indicating that in the absence of CD8 cells, Ad5mTRAIL+CpG therapy was no longer effective (Fig. 3B). Here, CD8A is linked to kidney neoplasm.