In contrast, we now find that in mice with orthotopic Renca tumors, depletion of CD4 T cells in Ad5mTRAIL+CpG-treated mice results in larger tumor burdens (Fig. 3 and 5), indicating that CD4 T cells are directly contributing to tumor clearance and/or providing the necessary help to generate an optimal CD8 T cell response. The gene discussed is CD4; the disease is neoplasm.