Use of Ad5mTRAIL+CpG as an adjunct therapy to nephrectomy would require careful examination of the timing between immunotherapy administration and surgery, as TRAIL-induced apoptosis of tumor cells, apoptotic body uptake by local DC, and activation of naive tumor antigen-specific T cells would need to occur prior to removal of the tumor-bearing kidney. Here, TNFSF10 is linked to neoplasm.