In fact, tumor tissue remodeling is necessary for the initiation of angiogenesis and occurs in a dynamic fashion [74], with a downregulation of antiangiogenic secreted proteases, such as ADAMTS-8 in brain tumors [107], and increased secretion of proangiogenic matrix metalproteases (MMPs), such as MMP2 and MMP9 [58, 67]. This evidence concerns the gene MMP9 and neoplasm.