Particularly important to the immune tolerogenic properties of the tumor are the effects of TGF-β secretion [59], including suppression of T-cell adaptive and natural killer (NK) cell innate antitumor responses, recruitment of suppressive myeloid cell subsets such as suppressive dendritic cells, TAMs, and MDSCs, and recruitment of regulatory T cell activity [7, 12, 59, 73]. Here, TGFB1 is linked to neoplasm.