First, parallelly elevated plasma IL-12, IL-17, and CXCL10 concentrations exhibited positive correlation with the SLEDAI in their lupus patients with renal impairment, which supported that these cytokines cascade could play a pathological role in the development of autoinflammatory response in SLE patients with severe disease, through the recruitment of the effector leukocytes into the inflamed tissue for orchestrating the immunoresponse at the site of inflammation. This evidence concerns the gene CXCL10 and systemic lupus erythematosus.