A recent study [93] had shown that CXCL13 and IL-21 may relate with the immunopathogenesis mediated by the function of TFH cells in SLE as serum level of all these cytokines were found to be significantly elevated in lupus patient with the increase in CXCL13 concentration correlated positively and significantly with SLEDAI score. The gene discussed is IL21; the disease is systemic lupus erythematosus.