Although cases of HCV-related peripheral neuropathy responsive to antiviral therapy with IFNα and ribavirin have been described [136], several authors have reported an aggravation of pre-existing MC-related neuropathy or even de novo occurrence of demyelinating polyneuropathy during IFN-α or PEG-IFN-α treatment [137]. The gene discussed is IFNA1; the disease is demyelinating polyneuropathy.