Several studies in genetics and molecular biology have improved our understanding of this malignancy, and it is clear that a host of tumor markers such as NSE, hyaluronic acid, carcinoembryonic antigen (CEA), AFP, and even paraneoplastic syndromes that are attributable to the hormonal secretion of erythropoietin and renin are produced in WT [131]. This evidence concerns the gene AFP and neoplasm.