TP53 and colorectal carcinoma: These studies have shown that many proteins involved in key signaling pathways of CRC, such as members of the Wnt/β-catenin and phosphatidylinositol-3-kinase (PI-3-K) pathways, KRAS, p53, extracellular matrix regulators, as well as epithelial-mesenchymal transition (EMT) transcription factors, are altered and seem to be affected by miRNA regulation in CRC [62].