INSR and colorectal carcinoma: On the other hand, the first epidemiological study showing an association between microRNA-binding SNP sequences and cancer risk was performed by Landi and co-workers [101] through a case-control study that examined the association of eight polymorphisms within microRNA-binding sites with the risk of sporadic CRC, founding that the variant alleles of CD86 and INSR genes were strongly associated with the risk of CRC.