Different pathway have been described as implicated in drug cancer resistance such as decreased uptake of water-soluble drugs, increased repair of DNA damage, reduced apoptosis, altered metabolism of drugs and increased energy-dependent efflux of chemotherapeutic drugs that diminish the ability of cytotoxic agents to kill cancer cell, changes in glutathione transferase, topoisomerase II and in microtubule related genes expression. The gene discussed is HPGDS; the disease is cancer.