Angiopoietin-2 (Ang-2), C-C motif chemokine receptor 7 (CCR7), CCR8, CCR9, ciliary neurotrophic factor (CNTF), C-X-C motif chemokine ligand 14 (CXCL14/BRAK), C-X-C motif chemokine receptor 1 (CXCR1/IL-8 RA), CXCR2 (IL-8 RB), EGF-TM7 latrophilin-related protein (ETL), insulin-like growth factor binding protein-related protein 1 (IGFBP-rp1/IGFBP-7), and insulysin (insulin-degrading enzyme/IDE) were decreased in the aqueous humor of patients with AMD. The gene discussed is IDE; the disease is age-related macular degeneration.