Kinases BUB1, CHEK1, IRAK1, TTK, RYK, and VRK2, identified in this study, for example, have been reported to be highly overexpressed in ER-negative breast tumors and were critical for the growth of either ER-negative only or both ER-positive and -negative breast cancer cells [9,23]. The gene discussed is ESR1; the disease is breast carcinoma.