The results showed that the serum AFP index, FGF19 mRNA level, and intrahepatic metastasis were significant predictors of disease-free survival (P = 0.004, 0.021, and 0.020, respectively), while Milan criteria, serum AFP index, FGF19 mRNA level, tumor size, and intrahepatic metastasis were significant predictors of overall survival (P = 0.006, 0.042, 0.018, 0.028 and 0.020, respectively). The gene discussed is FGF19; the disease is neoplasm.