The proliferation index was highest when the concentration of FGF19 was 1 ng/mL in the 5 HCC lines, whereas apoptosis of HCC cells was significantly suppressed by addition of 1 ng/mL FGF19 recombinant protein in culture media (Figure 5A; n = 12, P < 0.05). Here, FGF19 is linked to hepatocellular carcinoma.