An association between the ACE c.2306-117_404 D allele and the severity of CAD, described by the number of narrowings of 50% or higher and by the number of critical arterial occlusions has been reported in a Polish population (Niemiec et al. 2008a), analyzed as a whole, of 172 young (30-55 years old) subjects diagnosed with CAD. This evidence concerns the gene ACE and coronary artery disorder.