Also, the results of meta-analysis (Sayed-Tabatabaei et al. 2003) investigating the association between the ACE c.2306-117_404 I/D polymorphism and the carotid artery intima-media thickness (IMT), used to detect the presence and to follow the progression of atherosclerosis, correspond with our work. The gene discussed is ACE; the disease is atherosclerosis.