We assessed the effect of 5 genetic variants located in TH1 lineage transcription factors on cord blood immune responses of 200 neonates, namely TBX21 (rs17250932 and rs11079788) and HLX1 (rs2738751, rs3806325 and rs12141189) (Table 1) which have previously been related to the development or protection from asthma [10], [14]. This evidence concerns the gene HLX and asthma.