ITGA6 and Familial prostate cancer: Due to multiple reports of a strong correlation between increased Wnt signaling and prostate cancer [28], we initially analyzed the outcome of iLRP5-mediated Wnt pathway induction in purified prostate basal epithelial stem cells (B/SCs), using markers Lin−, Sca-1+, CD49f+ (providing the moniker, LSC cells [29]).