When analyzing subjects with MCI who subsequently developed AD (i.e. subjects with prodromal AD) we found that the CCL2 levels in CSF obtained at baseline were significantly associated with a higher annual decrease in MMSE score (rs = 0.42, p = 0.004; Figure 1) and with a shorter time to conversion to AD (rs = −0.39, p = 0.006). The gene discussed is CCL2; the disease is Alzheimer disease.