POU5F1 and non-small cell lung carcinoma: In this context, we observed an association of Oct-4 expression with tumor cell proliferation in patients with weak VEGF-mediated angiogenesis, including MVD-negative and VEGF-negative subsets, indicating that Oct-4 still plays an important role in cell proliferation in NSCLC tumors, even those with weak MVD or VEGF status.