JAK2 and essential thrombocythemia: Leukocytes from ET patients harboring the JAK2 V617F mutation showed higher expression of PRV1 (median = 4.88) in comparison to those negative for the JAK2 V617F mutation (1.91) (p = 0.0074) (Figure 6A) and, consequently, a positive correlation between PRV1 expression and JAK2 V617F allele burden was observed in ET patient leukocytes (r = 0.4785; p = 0.0067) (Figure 6B).