These GluN1 hypomorph (GluN1hypo) mice have been suggested as a mouse model of schizophrenia and have previously been shown to exhibit behavioral phenotypes relevant to schizophrenia such as deficits in prepulse inhibition (PPI, Duncan et al. 2004, 2006a,b; Fradley et al. 2005; Moy et al. 2006), reduced social interaction (Duncan et al. 2004; Halene et al. 2009; Mohn et al. 1999), hyperactivity (Duncan et al. 2006b; Mohn et al. 1999) and increased stereotypy (Mohn et al. 1999). Here, GRIN1 is linked to schizophrenia.