For instance, while van Bavel and colleagues identified in a subset of patients with SLE autoantibodies against acetylated histone H2B tails [28], histone H4 [29] and histone H3K27Me3 [30], the relationship of these marks to those within NETs remains unclear, and SLE autoantibodies may recognize other histone PTMs. This evidence concerns the gene H2BC12L and systemic lupus erythematosus.