In the T54 COPD cohort, 22% of patients had a history of myocardial infarction or ischemic cardiac events; however, neither increased levels of creatine kinase-MB and myoglobin nor decreased FEV1 were associated with history of these cardiac events (for online supplement - Figure S1, see Additional file 6; for the figure legend, see Additional file 1). Here, MB is linked to chronic obstructive pulmonary disease.