Treatment of OSC19 cells with GSPs down-regulates the expression of these NF-κB-targeted proteins, which supports the evidence that NF-κB has a role in invasion of HNSCC cells, and that the inhibitory effect on cell invasion by GSPs is mediated, at least in part, through the inactivation of NF-κB. The gene discussed is NFKB1; the disease is head and neck squamous cell carcinoma.