DNAJC17 and cyclic hematopoiesis: This locus overlaps HTRC2. From a subsequent transcriptional assay and sequencing of candidate genes, they concluded that the amino acid substitution of highly conserved tyrosine 273 to phenylalanine in Dnajc17 (119.0 Mb), encoding for a member of the type III heat-shock protein-40 family, results in reduced thyroglobulin (Tg) transcription, leading to CH in B6 mice [21].