Consequently, a potential mechanism of LGMD2H pathology might be the destabilization of mutated TRIM32 protein leading to a null phenotype.TRIM32 belongs to the TRIM-NHL family that is characterized by the presence of an N-terminal RING finger, one or more Zinc-finger-like motifs called B-boxes, a coiled coil region and a C-terminal NHL domain [6]. The gene discussed is TRIM32; the disease is autosomal recessive limb-girdle muscular dystrophy type 2H.