These include differential expression and splicing of calcium transporter (SLC8A1, CACNB2, RYR1) and energy metabolism (COX4I1, ACAT1, ATP5A1) genes, as well as structural proteins (STPB, DCTN5, XIRP2), detectable in myocardial samples obtained from HLHS patients during surgical intervention. This evidence concerns the gene CACNB2 and hypoplastic left heart syndrome.