These include differential expression and splicing of calcium transporter (SLC8A1, CACNB2, RYR1) and energy metabolism (COX4I1, ACAT1, ATP5A1) genes, as well as structural proteins (STPB, DCTN5, XIRP2), detectable in myocardial samples obtained from HLHS patients during surgical intervention. Here, DCTN5 is linked to hypoplastic left heart syndrome.