SHH is not only a mediator of angiogenesis but has also been shown to induce vessel formation in endothelial cells [51] and activate expression of angiopoietins I and II, and VEGF-signaling proteins from mesenchymal cells, highlighting the significance of tumor-associated fibroblasts in combination with canonical Hh signaling to mediate blood vessel formation [52]. The gene discussed is VEGFA; the disease is neoplasm.