Additionally, the authors highlighted collagenase-1 (MMP1), angiopoietin-like 4 (ANGPTL4), latent TGF-β-binding protein (LTBP1), and fascin-1 (FSCN1) as genes that were upregulated in the brain-seeking population and thus, potential mediators of brain metastasis, providing more insight into possible tumor-specific therapeutic targets. Here, ANGPTL4 is linked to neoplasm.