For example, the nomogram can be used to calculate the risk of residual nodal disease in a 62-year-old woman who presents after a lumpectomy revealing a 1.5 cm, grade 2 invasive ductal carcinoma, hormone receptor-negative, with no lymphovascular invasion and an SLN biopsy yielding 3 negative nodes. The gene discussed is NR4A1; the disease is invasive ductal breast carcinoma.