VEGFC and metastatic malignant neoplasm in the lymph nodes: In a retrospective study of 61 cases, it was reported that LVD may serve as a predictor of lymph node metastasis and a prognostic factor, whereas VEGF-C and VEGF-D may play important roles in lymphangiogenesis, making the carcinoma more aggressive and leading to a poor prognosis in breast cancer [8].