Furthermore, in the neoadjuvant lapatinib and/or trastuzumab treatment optimisation (Neo-ALTTO trial), 455 preoperative breast cancer patients with HER2-positive tumors received an initial 6 weeks of lapatinib, trastuzumab, or their combination, followed by another 12 weeks of the same anti-HER2 therapy plus wkly-PTX prior to definitive surgery. This evidence concerns the gene ERBB2 and breast cancer.