Quantification of the number of CD4+, CD8+ and FOXP3+ T-lymphocytes in progressive disease indeed confirmed a lower number of positive cells located on the endometrial-myometrial border (Fig. 1B, EM), at the edge of the tumor (Fig. 1B, Tumor Edge) and within the tumor (Fig. 1B, Intratumoral). Here, CD4 is linked to neoplasm.