For L1CAM, regulation of transcription by TGF-β signaling has been described [60], but, interestingly, in colorectal cancer L1CAM has also been shown to be a target gene of Wnt/β-catenin signaling and expression of L1CAM was found to co-localize with β-catenin in the invasive front of the tumor [61]. The gene discussed is TGFB1; the disease is colorectal cancer.