Furthermore, it was also noted that a number of pathways specifically involved in transition from a epithelial state to a mesenchymal state (EMT) was significantly regulated by progesterone and in the endometrial cancer samples: EGF signaling (p = 0.029), IGF-1 signaling (p = 0.0000006), IL-6 signaling (0.013), ILK signaling (p = 0.018), PDGF signaling (p = 0.03), TGF-β (p = 0.003), VEGF signaling (p = 0.022) and Wnt/β-catenin signaling (p = 0.036). The gene discussed is IGF1; the disease is endometrial cancer.