For melanoma, the top five 1-gene signatures, OAS3 (82.9% on training and 71.4% on testing set), RALBP1 (82.9% on training and 71.4% on testing set), GLA (80.4% on training and 71.4% on testing set), LLGL1 (80.4% on training and 71.4% on testing set) and SERPINA6 (80.4% on training and 71.4% on testing set), all have better than 80% classification accuracy between melanoma cases and control cases in the test set. Here, OAS3 is linked to melanoma.