ITGA6 and leukemia: Because ITGB4 and ITGA6 form a heterodimer that binds to the laminin receptor and treatment with a neutralizing antibody to ITGB3 did not suppress the cell adhesion ability of EVI1high leukemia cells (Fig. 3G), we further characterized the relationship between the expression of ITGA6/ITGB4 and the increased adhesion ability of the EVI1high leukemia cells.