To support our data, we examined the expression patterns of ITGA6/ITGB4 and VLA-4 (ITGA4/ITGB1) heterodimers by comparing the gene expression profiles of EVI1high and EVI1low AML deposited in Gene Expression Omnibus (GSE6891, GEO in NCBI website) [29]. Here, ITGB4 is linked to acute myeloid leukemia.