Two EVI1low (K562 and U937) and three EVI1high (UCSD/AML1, PT9 and PT11) leukemia cell lines were co-cultured with MC3T3-E1 cells, and the mixed cultures were subsequently treated with anti-ITGA6 or anti-ITGB4 antibody or the control isotype anti-rabbit IgG. Here, ITGB4 is linked to leukemia.