To evaluate whether the adhesion ability of the EVI1high leukemia cells was specifically dependent on the expression of ITGA6 or ITGB4, shRNA against ITGA6 or ITGB4 was introduced into UCSD/AML1 cells using an Amaxa Nucleofector, and the cell adhesion ability to matrigel was determined. The gene discussed is ITGA6; the disease is leukemia.