Two days after treatment, the binding activity of all four cell lines was significantly reduced by the treatment with anti-ITGA6 or anti-ITGB4 antibodies; however, isotype IgG, anti-ITGB2 or anti-ITGB3 antibodies did not inhibit the binding of EVI1high leukemia cells to matrigel (Fig. 3G). Here, ITGB4 is linked to leukemia.