Moreover, ITGB4, ITGA6, ITGA9, and VE-cadherin were also downregulated in the HNT34 cell line, and PT9 and PT11 primary AML cell lines upon shEVI1 transfection, which was associated with a reduction in matrigel cell adhesion (Figs. S1C to F). Here, ITGB4 is linked to acute myeloid leukemia.