Moreover, the induction of PI-3K/AKT/Bcl-2 signaling through the VLA-4-fibronectin interaction results in resistance to anoikis and drug-induced apoptosis [21]; we also showed the cell adhesion of EVI1high AML cells to matrigel induced expression of BCL and phosphorylation of AKT (data not shown). This evidence concerns the gene FN1 and acute myeloid leukemia.