Moreover, the induction of PI-3K/AKT/Bcl-2 signaling through the VLA-4-fibronectin interaction results in resistance to anoikis and drug-induced apoptosis [21]; we also showed the cell adhesion of EVI1high AML cells to matrigel induced expression of BCL and phosphorylation of AKT (data not shown). Here, BCL2 is linked to acute myeloid leukemia.