This is supported by the demonstration that CaSR is expressed in the arterial wall [26], both in vascular arterial endothelial and in smooth muscle cells [10], [11], [32], as well as by animal model studies showing a direct significant beneficial effect by R-568 on hypertension and on calcification and vascular remodelling in both uremic and control rats [17]. This evidence concerns the gene CASR and Hypertension.