NR3C1 and major depressive disorder: Lee and colleagues [42] found that chronic oral corticosterone administration caused anxiety-like behavior and a decrease in hippocampal and blood mRNA levels of NR3C1. Moreover, the relevance of regulation of leukocyte glucocorticoid receptor expression for stress-related disorders is supported by evidence of abnormal sensitivity and expression of this receptor in leukocytes of patients with major depression and post-traumatic stress disorder [53], [54].