Activated NF-κB was necessary for inflammasome formation during infection (Streptococcus pyogenes, Vibrio) [45], [51] or stimulation with various ligands/agents (TLR4 ligand LPS, TLR2/1 ligand Pam3CysSK4, silica) [42], [43]. The gene discussed is NFKB1; the disease is infection.