TLRs/MyD88 was required for inflammasome assembly after infection [vaccinia virus (TLR2/6), Candida albicans (TLR2), Vibrio (MyD88)] and stimulation with DAMPs [biglycan (TLR2/4)], environmental particles [alkane particles (TLR2)] or fungal components [zymosan and mannan (TLR2)] [51]–[55], [77]. The gene discussed is BGN; the disease is infection.