Inactivation of caspase-8 by hypermethylation of regulatory sequences of the caspase-8 gene occurs in several human cancers in addition to RMS, for example, in neuroblastoma, medulloblastoma, Ewing tumors, and small-cell lung cancer both in cell lines as well as in primary tumor samples [20]. The gene discussed is CASP8; the disease is small cell lung carcinoma.