KIT and systemic mastocytosis: Preliminary results of a multicenter, phase II study of midostaurin (100 mg twice daily) in 26 patients with ASM, mast cell leukemia, or systemic mastocytosis without an associated hematologic clonal nonmast cell lineage disease (AHNMD) demonstrated that patients achieved a high overall response rate of 69%, regardless of c-KIT mutation status [10].