Similar to univariate analysis, after adjustment, PIK3CA amplification was still significantly associated with higher mortality (OR = 3.50, 95% CI = 1.36-9.00; P < 0.05), and PIK3CA mutations remained positively associated with tumor differentiation (OR = 5.53, 95% CI = 0.65-47.4) (Table 2). Here, PIK3CA is linked to neoplasm.