NFKB1 and neoplasm: Downstream genes responsible for the tumor-promoting role of NF-κB have been studied exhaustively, such as antiapoptic gene, c-FLIP, Bcl-XL and IAP family member [30-32]; cell cycle regulator, cyclin D1 [33] and genes referring to environmental modification, vascular endothelial growth factors (VEGF) [34] and matrix metalloproteinases (MMPs)[35].