A recent multivariate analysis has shown that factors predicting HIV-1 associated failure-to-thrive (FTT) in children born to HIV-positive mothers include history of pneumonia, maternal illicit drug use during pregnancy, lower infant CD4 T-cell count, exposure to antiretroviral therapy by 3 months of age (non-protease inhibitor), and HIV-1 RNA viral load [141]. The gene discussed is CD4; the disease is Failure to thrive.